This might be a crime scene
Thursday, 13 Mar 2025
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If you’re in pain but you can’t feel it… are you actually in pain?
This is a semantics thing, the original question was ‘where’ does the pain killer go and not how the pain killer works. The vick guy was right in pointing out the original question was not answered.
No no no why are you all letting this man take a victory lap? That really didn’t answer the question of “how do they know”
The answer is “Interested pain killers don’t know where to go. The only pain killers that go to a specified place are locals. Otherwise they get into your blood and go every where and go after every thing which is why your end up high and end up developing addiction. If morphine was smart enough to go to your pain you wouldn’t become addicted. They aren’t smart bombs for pain. They’re carpet bombs.
THEN you can drop the factoid about pain you can’t feel happening anyway.
Reddit
He didn’t answer the question. He answered how they work, but not how it knows where to go. The answer is that it doesn’t. It enters your blood stream and goes everywhere.
How does it know where swelling is to make it go down🤣
*OPEN THE SCHOOLS!*
They don’t know, they block signals everywhere, you just realise ot works where the pain was because you’re focused on that particular part already
More like get hit by it
You get on the bus tho, amirite or amirite?
Why is everyone talking about the question and painkillers? Isn’t this sub meant to be about the rare insult? Who cares if the guy didn’t explain it all that well.
Doesn’t really work when he’s in the wrong
Ok but what the hell was vick on about like he literally did??? 😭
Long or Short bus?
(Asking for a friend)
If being a “really chill guy” means saying things like Vick, then I don’t wanna be chill.
David: The thermos is the greatest invention of all time
Sarah: All it does is keep hot things hot and cold things cold
David: But how does it know???
Yeah, go to school dummy. Every high schooler knows that binding of the opioid ligand to the orthosteric site, facilitates G proteininteraction and guanine nucleotide (guanosine diphosphate [GDP] for guanosine triphosphate [GTP]) exchange on the α subunit which dissociates from the β/γ dimer. The αi-GTP and variably β/γ dimer go on to inhibit adenylate cyclase to reduce cyclic adenosine monophosphate (cAMP), open inwardly rectifying K+ channels to hyperpolarise, close voltage gated Ca2+ channels and activate mitogen-activated protein kinases (MAPKs). The opioid signal is terminated by GTP metabolism back to GDP (the α subunit is also a GTPase enzyme) and after G protein-coupled receptor kinase (GRK) phosphorylation of the receptor, arrestin recruitment and eventual endocytosis.
Seems like molly”percocetz” would know more about pain pills….
This is a terrible explanation. “You’re still in pain but you don’t feel it”? What is an unfelt pain?
They should probably get in ambulance instead, get some treatment for that burn.
I mean. Didn’t really answer the question
So I know this isn’t askscience or whatever . But use case:
I have a headache and I go to sleep with it. I wake up 3 hours later and still have the headache . I take a Tylenol and wake up again in another 3 hours with no headache. The headache doesn’t return again.
What’s actually happened here. Was there just some condition that stopped occurring after 6 hours to eliminate the source of the pain over the duration of the Tylenols active period ?
Something makes the headache subside or else we’d just forever be popping them every 12 hours .